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Antidote for paracetamol overdose
Pharmacology · exam-style practice question with explanation
What is the antidote for paracetamol (acetaminophen) overdose?
- A. Naloxone
- B. N-acetylcysteine
- C. Flumazenil
- D. Atropine
Show the answer and explanation
Answer: B. N-acetylcysteine
N-acetylcysteine replenishes glutathione, which detoxifies the toxic paracetamol metabolite NAPQI and protects the liver. It works best within 8 hours of ingestion, but should still be given to late presenters.
Key point: Paracetamol overdose: N-acetylcysteine.
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