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First-line drug for eclamptic seizures
Obstetrics & Gynaecology · exam-style practice question with explanation
A woman at 36 weeks' gestation with severe pre-eclampsia has a generalised seizure. Which drug is first-line to control and prevent further seizures?
- A. Diazepam
- B. Magnesium sulphate
- C. Phenytoin
- D. Labetalol
Show the answer and explanation
Answer: B. Magnesium sulphate
Magnesium sulphate is first-line for treating and preventing eclamptic seizures, and works better than diazepam or phenytoin. Watch for toxicity: loss of patellar reflexes, slow breathing and low urine output. The antidote is calcium gluconate. Delivery is the definitive treatment.
Key point: Eclampsia: magnesium sulphate; antidote calcium gluconate.
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